Isatin Manufacturer & Supplier in India
Isatin Manufacturer & Supplier in India — CAS 91-56-5
What is Isatin?
Isatin is a naturally occurring bicyclic compound belonging to the indole family, registered under CAS number 91-56-5, with the molecular formula C₈H₅NO₂ and a molecular weight of 147.13 g/mol. Its IUPAC name is 1H-indole-2,3-dione, reflecting its defining structural feature — a benzene ring fused to a five-membered ring containing both a lactam and a lactone carbonyl group at the 2 and 3 positions respectively.
What makes Isatin particularly significant as a synthetic building block is the versatility of its reactive sites. The two carbonyl groups at positions 2 and 3, combined with the nitrogen atom at position 1, give Isatin a rich and well-documented reactivity profile — enabling condensation reactions, nucleophilic additions, ring-opening transformations, and heterocyclic synthesis across a wide range of chemical contexts. This multi-point reactivity is why Isatin features in synthesis programmes spanning pharmaceuticals, specialty dyes, and advanced materials research.
Isatin is also notable for its natural occurrence — it has been identified in several plant species and in trace quantities in human physiological fluids, a property that has driven significant academic and pharmaceutical research interest in its biological activity and derivatives.
At Advance Pharma Chem, Isatin is manufactured under controlled process conditions with in-house quality verification at every production stage, ensuring the consistency and purity that both pharmaceutical synthesis and specialty dye manufacturing demand.
Product Specifications
| Product Name | Isatin |
|---|---|
| CAS Number | 91-56-5 |
| Molecular Formula | C₈H₅NO₂ |
| Molecular Weight | 147.13 g/mol |
| IUPAC Name | 1H-indole-2,3-dione |
| Synonyms | 2,3-Dioxoindoline, 1H-Indole-2,3-dione, 2,3-Indolinedione |
| Appearance | Orange to red-orange crystalline solid (shade may vary slightly depending on synthesis route and crystal size — consistent with standard Isatin) |
| Packaging | Custom quantities on request — from gram-scale R&D batches to bulk commercial volumes |
| Availability | In stock — India & international supply |
| Certifications | ISO 9001:2015 |
| COA | Available on request per batch |
| MSDS | Available on request |
Storage, Handling & Safety
The following is a general guidance summary for laboratory and procurement personnel. A full Material Safety Data Sheet (MSDS) is available on request.
| Storage Conditions | Store in a cool, dry, well-ventilated place away from direct light and moisture |
|---|---|
| Container | Keep in tightly sealed original container |
| Handling Precautions | Avoid inhalation of dust or vapours. Use appropriate PPE — gloves, safety glasses, and lab coat recommended |
| GHS Hazard Classification | Irritant — refer to full MSDS for GHS pictograms and signal words |
| Incompatibilities | Strong oxidising agents, strong bases, moisture |
| MSDS | Available on request — contact us with your enquiry |
The above is a general guidance summary. Always refer to the full MSDS before handling. Regulatory classifications may vary by jurisdiction.
Applications of Isatin
Isatin is one of the more versatile intermediates in Advance Pharma Chem’s portfolio, serving active roles in both regulated pharmaceutical synthesis and high-value specialty dye manufacturing. Its dual-market relevance reflects the breadth of its chemical reactivity and the depth of research interest it has attracted across multiple industries over decades.
Pharmaceutical Applications
Dibucaine and Cinchocaine — Local Anaesthetic Synthesis
One of the primary pharmaceutical applications of Isatin is as an intermediate in the synthesis of Dibucaine, also known as Cinchocaine — a potent, long-acting local anaesthetic of the amide class. Dibucaine is used clinically for spinal anaesthesia and topical pain relief, and is listed on several national essential medicines frameworks reflecting its established role in surgical and procedural medicine. For API manufacturers working in the anaesthetic drug segment, Isatin provides a well-characterised and reliable entry point into the synthesis pathway.
Anti-Cancer Research — Isatin Derivatives as Promising Scaffolds
Isatin and its derivatives have attracted growing research interest as scaffolds in anti-cancer drug discovery. Numerous published studies have documented the cytotoxic activity of Isatin-derived compounds against a range of cancer cell lines, with research programmes exploring their potential as kinase inhibitors, apoptosis inducers, and multi-target anti-tumour agents. While this remains an active area of research rather than a fully commercialised application, the demand for high-purity Isatin from pharmaceutical research organisations, academic institutions, and drug discovery companies working in oncology is well established and growing. We supply gram-scale quantities specifically to support research and screening programmes at this stage of development.
Anti-Retroviral Research — HIV and Related Drug Development
Isatin derivatives have also shown promise in anti-retroviral research, with studies identifying Isatin-based compounds as potential inhibitors of enzymes critical to HIV replication. Research in this area has positioned Isatin as a relevant starting material for medicinal chemistry programmes targeting HIV and related retroviral conditions. Organisations involved in anti-retroviral drug development and research represent an important buyer segment for pharmaceutical-grade Isatin, including those working at early discovery scale requiring smaller controlled quantities.
Specialty Dye & Pigment Applications
Solvent Yellow 114 — Specialty Dye Intermediate
In the specialty chemicals and dye manufacturing segment, Isatin serves as a key intermediate in the production of Solvent Yellow 114 — a high-performance solvent dye used for the colouration of plastics, waxes, lacquers, and hydrocarbon-based products. Solvent Yellow 114 is valued for its strong tinctorial strength, excellent solubility in organic systems, and thermal stability under processing conditions. For specialty dye manufacturers requiring a consistent, quality-verified source of Isatin, Advance Pharma Chem offers direct supply from an ISO-certified manufacturing facility.
Broader Dye and Pigment Synthesis
Beyond Solvent Yellow 114, Isatin’s reactive carbonyl groups make it a useful precursor in the synthesis of a broader range of indole-based dyes and pigments. Its established place in dye chemistry — particularly in programmes involving vat dyes and specialty colourants — means that demand for Isatin spans both large-scale dye manufacturers and smaller specialty chemicals producers working on custom colour solutions.
Why Source Isatin from Advance Pharma Chem?
14+ Years of Pharmaceutical and Specialty Intermediate Manufacturing
Advance Pharma Chem has been manufacturing complex organic intermediates since 2011, with a portfolio that spans both pharmaceutical and specialty chemicals applications. Our process chemistry team brings deep hands-on expertise to every compound we manufacture — including Isatin, where consistent purity, controlled morphology, and reliable batch-to-batch quality are non-negotiable requirements for both downstream synthesis segments this compound serves.
ISO 9001:2015 Certified Quality Management
Our manufacturing operations are certified under ISO 9001:2015, covering in-process quality checks, finished goods verification, and documentation practices. Every batch of 5-Bromo-2-Chloropyrimidine is accompanied by a Certificate of Analysis. For pharmaceutical buyers operating under GMP-adjacent procurement requirements, our quality system provides the assurance your vendor qualification process demands.
ISO 9001:2015 Certified Quality Management
Our manufacturing operations are certified under ISO 9001:2015, with documented quality control covering raw material intake, in-process monitoring, and finished goods verification. Every batch of Isatin is accompanied by a Certificate of Analysis. Whether you are a pharmaceutical buyer with GMP-adjacent procurement requirements or a specialty dye manufacturer with strict colour-consistency standards, our quality system is built to meet both.
Direct Manufacturer & Exporter
We are both the manufacturer and the exporter — no intermediary sits between our production facility and your supply chain. As an established Isatin supplier in India with direct export capability, we manage all associated documentation: COA, MSDS, and destination-specific customs and regulatory paperwork. This eliminates the quality dilution and communication delays that come with trading intermediaries.
Serving Both Pharma and Specialty Dye Buyers
Unlike suppliers who specialise exclusively in one segment, Advance Pharma Chem has active supply relationships across both pharmaceutical and specialty chemicals industries. This means we understand the different quality expectations, documentation requirements, and supply cadences of each — and we can serve both without compromise. Whether your application is a regulated API synthesis programme, an oncology research project, or a specialty dye manufacturing run, our team speaks your language.
Custom Supply from Gram-Scale R&D to Multi-Tonne Commercial Volumes
Whether you are a researcher requiring gram-scale quantities for process development or oncology screening, a CDMO working through a client-committed synthesis campaign, or a commercial manufacturer requiring consistent bulk volumes across production cycles, our supply model is structured around your requirement — not a fixed catalogue. We do not impose minimum order quantities that price out legitimate research buyers. Every enquiry — regardless of scale — is treated seriously and responded to within 24 business hours.
Trusted by CRAMS, CDMO and Specialty Chemicals Companies
Our client base has grown from 2 organisations in 2021 to over 20 in 2025 — spanning pharmaceutical CRAMS and CDMO companies as well as specialty chemicals manufacturers. This breadth of active relationships across two distinct industry segments reflects the versatility of our manufacturing capability and the consistency our clients have come to rely on.
Competitive Pricing Across All Order Sizes
Sourcing Isatin directly from an Indian manufacturer with established in-house process chemistry eliminates the cost premium associated with import dependency and intermediary margins. For buyers evaluating Isatin manufacturers and suppliers in India — whether for research quantities or commercial bulk — our pricing reflects genuine manufacturing efficiency. Long-term supply agreements and volume-based pricing are available for buyers with recurring requirements across either application segment.
Related Products You May Also Need
Customers sourcing 2-Hydroxy-1-Naphthaldehyde often also require the following intermediates from our portfolio:
- Isatin (CAS 91-56-5) — Pharma intermediate & Solvent Yellow 114 precursor
- 7-Chloroquinaldine (CAS 4965-33-7) — Montelukast Sodium MK-1 intermediate
- 3-Hydroxyquinaldine-4-carboxylic acid (CAS 117-57-7) — Solvent Yellow 114 & Disperse Yellow 54 intermediate
- 4-Diethylamino salicylaldehyde (CAS 17754-90-4) — Specialty dye intermediate for Solvent Yellow 172, Coumarin 7
View our complete product range on the Pharma Intermediate and Specialty Intermediate pages.
Frequently Asked Questions
What is Isatin used for?
Isatin (CAS 91-56-5) is a versatile intermediate used across two distinct industries. In pharmaceuticals, it is used in the synthesis of Dibucaine and Cinchocaine (local anaesthetics) and serves as a research scaffold in anti-cancer and anti-retroviral drug discovery programmes. In specialty chemicals, it is a key intermediate in the manufacture of Solvent Yellow 114 and other indole-based dyes and pigments.
Who are the manufacturers and suppliers of Isatin in India?
Advance Pharma Chem is an established Isatin manufacturer and supplier in India, operating under an ISO 9001:2015 certified quality management system. We supply pharmaceutical-grade and specialty-grade Isatin directly from our production facility to customers across India and internationally — from gram-scale research quantities to large commercial bulk volumes.
What is the CAS number for Isatin?
The CAS number for Isatin is 91-56-5. It is also known by the synonyms 2,3-Dioxoindoline, 1H-Indole-2,3-dione, and 2,3-Indolinedione — all referring to the same compound.
What is the molecular formula of Isatin?
The molecular formula is C₈H₅NO₂ with a molecular weight of 147.13 g/mol.
What does Isatin look like?
Isatin typically appears as an orange to red-orange crystalline solid under standard conditions.
Why does the colour of Isatin sometimes vary between batches or suppliers?
Isatin’s characteristic orange to red-orange colour can vary slightly depending on the synthesis route employed, particle size distribution, and storage conditions. This is a well-documented property of the compound and does not indicate a quality deficiency. Each batch supplied by Advance Pharma Chem is accompanied by a Certificate of Analysis confirming identity and quality parameters. If you have specific colour or appearance requirements for your application, please mention them at the time of enquiry.
Is Isatin used in pharmaceutical or specialty dye manufacturing?
Both. Isatin is one of the few intermediates that serves active roles in both regulated pharmaceutical synthesis — including local anaesthetic and anti-cancer drug research — and specialty dye manufacturing, particularly for Solvent Yellow 114. Advance Pharma Chem supplies to buyers in both segments.
Do you supply Isatin in small quantities for research purposes?
Yes. We specifically supply gram-scale quantities for R&D, oncology research, and drug discovery programmes. Researchers and academic institutions are welcome to enquire — we do not impose commercial-scale minimum order quantities that make small research purchases impractical.
Can I buy Isatin in bulk from Advance Pharma Chem?
Yes. We supply custom quantities from small R&D and research batches through to large commercial bulk volumes. Contact us with your quantity requirement, intended application, and timeline and we will confirm availability, pricing, and lead time.
Is Advance Pharma Chem a manufacturer or a trader?
We are the manufacturer. Isatin is produced in-house at our ISO 9001:2015 certified facility. We do not source and resell — we manufacture and supply directly.
Do you export Isatin internationally?
Yes. We supply Isatin to customers across India and internationally. We assist with all required export documentation including COA, MSDS, and destination-specific customs and regulatory paperwork.
Is a Certificate of Analysis available for each batch?
Yes. A COA is issued for every manufactured batch of Isatin. Please mention your COA requirement at the time of enquiry and it will be included with your shipment documentation.
What are the storage conditions for Isatin?
Store in a cool, dry, well-ventilated place away from direct light and moisture, in a tightly sealed container. A full MSDS with comprehensive storage and handling guidance is available on request.
What is the lead time for Isatin orders?
Isatin is maintained in stock. Lead time depends on order quantity and current production schedule. Gram-scale research quantities and smaller development batches are typically fulfilled faster. We recommend contacting us early for large commercial bulk volumes.
Why is Isatin important in anti-cancer research?
Isatin and its derivatives have been extensively studied as scaffolds in anti-cancer drug discovery due to their documented cytotoxic activity against multiple cancer cell lines. Research programmes have explored Isatin-derived compounds as kinase inhibitors and apoptosis inducers, making high-purity Isatin a relevant procurement requirement for oncology-focused pharmaceutical research organisations and drug discovery companies — including those working at early discovery scale.
What is Solvent Yellow 114 and how is Isatin used in its manufacture?
Solvent Yellow 114 is a high-performance specialty solvent dye used for colouring plastics, waxes, and hydrocarbon-based systems, valued for its thermal stability and tinctorial strength. Isatin serves as a key intermediate in its synthesis pathway, making it an essential procurement input for specialty dye manufacturers producing this compound.
What is the difference between Isatin and its derivatives?
Isatin refers specifically to the parent compound 1H-indole-2,3-dione (CAS 91-56-5). Isatin derivatives are compounds synthesised from Isatin through chemical modification — such as N-substitution, condensation at the 3-position, or ring-opening reactions. Many of these derivatives are the actual target molecules in anti-cancer and anti-retroviral research programmes, with Isatin serving as the starting material or key intermediate in their synthesis.