5-Bromo-2-Chloropyrimidine
5-Bromo-2-Chloropyrimidine Manufacturer & Supplier in India
What is 5-Bromo-2-Chloropyrimidine?
5-Bromo-2-Chloropyrimidine is a dihalogenated pyrimidine derivative registered under CAS number 32779-36-5, with the molecular formula C₄H₂BrClN₂ and a molecular weight of 193.43 g/mol. The compound features a pyrimidine ring — a six-membered nitrogen-containing heterocycle — with a bromine substituent at the 5-position and a chlorine substituent at the 2-position.
This dual halogenation is precisely what makes 5-Bromo-2-Chloropyrimidine a highly valued building block in modern pharmaceutical synthesis. The bromine and chlorine substituents exhibit different reactivity profiles under specific coupling conditions, allowing medicinal chemists to perform selective cross-coupling reactions — such as Suzuki, Buchwald-Hartwig, and nucleophilic aromatic substitution — at one position while leaving the other intact for subsequent transformations. This selectivity makes it extremely difficult to substitute with simpler pyrimidine derivatives in multi-step API synthesis routes.
At Advance Pharma Chem, 5-Bromo-2-Chloropyrimidine is manufactured under a controlled process with in-house quality verification at every stage, delivering the purity and batch-to-batch consistency required by regulated pharmaceutical manufacturing environments.
Product Specifications
| Product Name | 5-Bromo-2-Chloropyrimidine |
|---|---|
| CAS Number | 32779-36-5 |
| Molecular Formula | C₄H₂BrClN₂ |
| Molecular Weight | 193.43 g/mol |
| IUPAC Name | 5-Bromo-2-Chloropyrimidine |
| Synonyms | 2-Chloro-5-Bromopyrimidine |
| Appearance | White to off-white crystalline solid |
| Packaging | Custom quantities on request |
| Availability | In stock — India & international supply |
| Certifications | ISO 9001:2015 |
| COA | Available on request per batch |
| MSDS | Available on request |
Storage, Handling & Safety
| Storage Conditions | Store in a cool, dry, well-ventilated place away from direct light and moisture |
|---|---|
| Container | Keep in tightly sealed original container |
| Handling Precautions | Avoid inhalation of dust or vapours. Use appropriate PPE — gloves, safety glasses, and lab coat recommended |
| GHS Hazard Classification | Irritant — refer to full MSDS for GHS pictograms and signal words |
| Incompatibilities | Strong oxidising agents, strong bases, moisture |
| MSDS | Available on request — contact us with your enquiry |
Note: The above is a general guidance summary. Always refer to the full MSDS before handling. Regulatory classifications may vary by jurisdiction.
Applications of 5-Bromo-2-Chloropyrimidine
5-Bromo-2-Chloropyrimidine is an established pharmaceutical intermediate used in the synthesis of several commercially important and clinically significant API molecules. Its selective dual-halogen reactivity makes it a preferred building block across cardiovascular and metabolic drug synthesis programmes.
Cardiovascular Applications
Aprocitentan — Endothelin Receptor Antagonist for Resistant Hypertension
5-Bromo-2-Chloropyrimidine serves as a key intermediate in the synthesis of Aprocitentan, a dual endothelin receptor antagonist developed for the treatment of resistant hypertension — a condition where blood pressure remains uncontrolled despite concurrent use of multiple antihypertensive agents. Aprocitentan has received regulatory approval and represents a clinically meaningful advance in the management of difficult-to-treat hypertension, making a reliable supply of its synthesis intermediates strategically important for manufacturers in the cardiovascular API space.
Macitentan — Pulmonary Arterial Hypertension Treatment
5-Bromo-2-Chloropyrimidine is also used as an intermediate in the synthesis of Macitentan, a dual endothelin receptor antagonist indicated for the long-term treatment of pulmonary arterial hypertension (PAH). Macitentan is an established commercial drug with significant global prescription volume, and API manufacturers working in the PAH segment require consistent, high-quality supply of 5-Bromo-2-Chloropyrimidine as a non-negotiable input to their synthesis process.
Metabolic & Lipid Management Applications
Obicetrapib — Next-Generation Lipid-Lowering Agent
5-Bromo-2-Chloropyrimidine is also an intermediate in the synthesis of Obicetrapib, a cholesteryl ester transfer protein (CETP) inhibitor under active clinical development for the treatment of hypercholesterolaemia and cardiovascular risk reduction. Obicetrapib has attracted significant clinical and commercial interest as a next-generation lipid-lowering agent, particularly for patients who do not achieve adequate LDL reduction with statins alone. As the drug advances through its development pipeline, demand for synthesis intermediates including 5-Bromo-2-Chloropyrimidine is expected to grow correspondingly.
Why Source 5-Bromo-2-Chloropyrimidine from Advance Pharma Chem?
14+ Years of Pharmaceutical Intermediate Manufacturing Expertise
Advance Pharma Chem has been manufacturing complex heterocyclic and halogenated pharmaceutical intermediates since 2011. Our process chemistry team brings deep hands-on expertise in pyrimidine chemistry — understanding not just how to manufacture 5-Bromo-2-Chloropyrimidine, but how to do so with the selectivity, yield consistency, and impurity control that downstream pharmaceutical synthesis demands. This depth of expertise is not replicated easily and is reflected in the trust our clients place in us across multi-year supply relationships.
ISO 9001:2015 Certified Quality Management
Our manufacturing operations are certified under ISO 9001:2015, covering in-process quality checks, finished goods verification, and documentation practices. Every batch of 5-Bromo-2-Chloropyrimidine is accompanied by a Certificate of Analysis. For pharmaceutical buyers operating under GMP-adjacent procurement requirements, our quality system provides the assurance your vendor qualification process demands.
Direct Manufacturer & Exporter
We are both the manufacturer and the exporter — there is no intermediary between our production facility and your receiving dock. As an established 5-Bromo-2-Chloropyrimidine supplier in India with direct export capability, we handle all associated documentation: COA, MSDS, and destination-specific customs and regulatory paperwork. This simplifies your procurement process and eliminates the quality risk that comes with trading intermediaries.
Custom Bulk Supply from Development to Commercial Scale
Our supply model is built around your project timeline. Whether you are in early process development and need a small evaluation quantity, or you are a commercial API manufacturer requiring consistent bulk volumes across production campaigns, we calibrate our output to your requirement. We do not impose fixed packaging tiers — every enquiry is treated on its own terms.
Trusted Partner for CRAMS and CDMO Organisations
The majority of our clients are pharmaceutical CRAMS and CDMO companies that depend on intermediates like 5-Bromo-2-Chloropyrimidine as inputs to client-committed API production schedules. Our growth from 2 clients in 2021 to over 20 active clients in 2025 reflects the consistency and reliability that this demanding customer segment requires — and that we consistently deliver.
Competitive Pricing on Bulk Orders
Sourcing directly from an Indian manufacturer with in-house process chemistry eliminates the cost layers associated with import dependency and trading intermediaries. For buyers evaluating 5-Bromo-2-Chloropyrimidine manufacturers and suppliers globally, our pricing reflects genuine manufacturing efficiency. Long-term supply agreements and volume-based pricing are available for buyers with recurring requirements.
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View our complete product range on the Pharma Intermediate and Specialty Intermediate pages.
Frequently Asked Questions
What is 5-Bromo-2-Chloropyrimidine used for?
5-Bromo-2-Chloropyrimidine (CAS 32779-36-5) is a pharmaceutical intermediate used in the synthesis of Aprocitentan and Macitentan — both endothelin receptor antagonists for hypertension and pulmonary arterial hypertension — and Obicetrapib, a next-generation lipid-lowering agent. Its dual halogen substitution pattern makes it a selective and non-substitutable building block in these synthesis routes.
Who are the manufacturers and suppliers of 5-Bromo-2-Chloropyrimidine in India?
Advance Pharma Chem is an established manufacturer and supplier of 5-Bromo-2-Chloropyrimidine in India, operating under an ISO 9001:2015 certified quality management system. We supply directly from our production facility to pharmaceutical companies, CRAMS, and CDMO organisations across India and internationally.
What is the CAS number for 5-Bromo-2-Chloropyrimidine?
The CAS number is 32779-36-5. It is also referred to as 2-Chloro-5-Bromopyrimidine — both names refer to the same compound with an identical molecular structure.
Can I buy 5-Bromo-2-Chloropyrimidine in bulk?
Yes. We supply custom quantities from development-scale batches to large commercial bulk volumes. Contact us with your quantity requirement and project timeline and we will confirm availability, pricing, and lead time.
Is Advance Pharma Chem a manufacturer or a trader?
We are the manufacturer. 5-Bromo-2-Chloropyrimidine is produced in-house at our ISO 9001:2015 certified facility. We do not source and resell — we manufacture and supply directly.
Do you export 5-Bromo-2-Chloropyrimidine internationally?
Yes. We supply to customers in India and internationally. We assist with all required export documentation including COA, MSDS, and destination-specific customs and regulatory paperwork.
Is a Certificate of Analysis available for each batch?
Yes. A COA is issued for every manufactured batch. Please mention your COA requirement at the time of enquiry and it will be included with your shipment documentation.
What are the storage conditions for 5-Bromo-2-Chloropyrimidine?
Store in a cool, dry, well-ventilated place away from direct light and moisture, in a tightly sealed container. A full MSDS with comprehensive storage and handling guidance is available on request.
What is the molecular formula of 5-Bromo-2-Chloropyrimidine?
The molecular formula is C₄H₂BrClN₂ with a molecular weight of 193.43 g/mol.
What is the difference between 5-Bromo-2-Chloropyrimidine and 2-Chloro-5-Bromopyrimidine?
They are the same compound. 2-Chloro-5-Bromopyrimidine is an alternative naming convention for 5-Bromo-2-Chloropyrimidine, both referring to CAS 32779-36-5 with an identical molecular structure.
Why is 5-Bromo-2-Chloropyrimidine important in pharmaceutical synthesis?
The compound’s value lies in the differential reactivity of its two halogen substituents. The bromine and chlorine groups respond selectively under different coupling reaction conditions — such as Suzuki coupling and nucleophilic aromatic substitution — allowing chemists to functionalise one position independently of the other. This selectivity is essential in the multi-step synthesis of Aprocitentan, Macitentan, and Obicetrapib, and cannot be easily replicated with simpler pyrimidine derivatives.
What is the lead time for orders?
The compound is maintained in stock. Lead time depends on order quantity and current production schedule. We recommend contacting us early for commercial bulk volumes. Development quantities are typically fulfilled faster.