7-Chloroquinaldine
7-Chloroquinaldine Manufacturer in India — CAS 4965-33-7
What is 7-Chloroquinaldine?
7-Chloroquinaldine is a halogenated quinoline derivative with the molecular formula C₁₀H₈ClN and a molecular weight of 177.63 g/mol, registered under CAS number 4965-33-7. It is also known by the synonym 7-Chloro-2-methylquinoline — a name that directly describes its structure: a quinoline ring with a chlorine substituent at the 7-position and a methyl group at the 2-position.
This specific substitution pattern is what makes 7-Chloroquinaldine a highly selective and difficult-to-substitute building block in pharmaceutical synthesis. The compound belongs to the broader quinoline class of nitrogen-containing heterocyclic aromatics, widely used across pharmaceutical, agrochemical, and specialty materials chemistry.
At Advance Pharma Chem, 7-Chloroquinaldine is manufactured through a controlled Skraup-based synthesis pathway, with in-house quality verification at every production stage — from raw material intake to finished goods — ensuring the batch-to-batch consistency that regulated pharmaceutical manufacturing demands.
Product Specifications
| Product Name | 7-Chloroquinaldine |
|---|---|
| CAS Number | 4965-33-7 |
| Molecular Formula | C₁₀H₈ClN |
| Molecular Weight | 177.63 g/mol |
| IUPAC Name | 7-Chloro-2-methylquinoline |
| Synonyms | 7-Chloro-2-methylquinoline, 7-Chloro-2-quinaldine |
| Appearance | Off-white to pale yellow crystalline solid |
| Packaging | Custom quantities on request |
| Availability | In stock — India & international supply |
| Storage Conditions | Store in a cool, dry, well-ventilated area away from direct sunlight |
| Certifications | ISO 9001:2015 |
| COA | Available on request per batch |
| MSDS | Available on request |
Storage, Handling & Safety
The following guidance is provided for laboratory and procurement personnel. A full Material Safety Data Sheet (MSDS) is available on request.
| Parameter | Guidance |
|---|---|
| Storage Conditions | Store in a cool, dry, well-ventilated place away from direct light and heat sources |
| Container | Keep in tightly sealed original container |
| Handling Precautions | Avoid inhalation of dust or vapours. Use appropriate PPE — gloves, safety glasses, and lab coat recommended |
| GHS Hazard Classification | Irritant — refer to MSDS for full GHS pictograms and signal words |
| Incompatibilities | Strong oxidising agents, strong acid |
| MSDS | Available on request — contact us with your enquiry |
Note: The above is a general guidance summary. Always refer to the full MSDS before handling. Regulatory classifications may vary by jurisdiction.
Applications of 7-Chloroquinaldine
7-Chloroquinaldine is a critical intermediate in two distinct industrial segments — regulated pharmaceutical synthesis and high-performance specialty dyes. Its precise reactivity profile makes it effectively non-substitutable in both downstream processes.
Pharmaceutical Applications
Montelukast Sodium — Asthma & Allergy Treatment
The most significant pharmaceutical application of 7-Chloroquinaldine is as a direct precursor in the preparation of the MK-1 intermediate, a key step in the synthesis of Montelukast Sodium. Montelukast Sodium is the active pharmaceutical ingredient in widely prescribed medications used globally for the long-term management of asthma and seasonal allergic rhinitis. It functions as a leukotriene receptor antagonist and is included on several national essential medicines lists, reflecting the scale and consistency of global demand.
For API manufacturers, CRAMS organisations, and CDMO companies working in the respiratory drug segment, a reliable, high-quality supply of 7-Chloroquinaldine is not optional — it is a supply chain dependency. Disruption at this intermediate stage directly impacts API production timelines.
Pretomanid Synthesis — Anti-TB Segment
7-Chloroquinaldine also finds application as a building block in research and development work related to anti-tuberculosis drug synthesis, particularly in programmes working within the broader nitroimidazole and heterocyclic chemistry space.
Specialty Dye & Pigment Applications
Quinophthalone Dyes for Plastics and LEDs
In the specialty chemicals segment, 7-Chloroquinaldine serves as a precursor in the synthesis of Quinophthalone dyes — a class of high-performance yellow dyes distinguished by exceptional lightfastness, thermal stability, and resistance to migration. These properties make them suitable for demanding applications such as the mass colouration of engineering plastics and the production of LEDs, where conventional dyes fail under processing temperatures or UV exposure. This extends the relevance of 7-Chloroquinaldine beyond pharma buyers to specialty dye manufacturers and materials companies.
Why Source 7-Chloroquinaldine from Advance Pharma Chem?
India’s First and Most Established Commercial Manufacturer
Advance Pharma Chem developed and commercialised the domestic manufacturing process for 7-Chloroquinaldine in India — a compound that was previously only available through imports. This was not a technology transfer or licensed process. It was developed entirely in-house by our team. When you source from us, you are sourcing from the originator of domestic production, not a trader, reseller, or secondary manufacturer.
14+ Years of Heterocyclic Process Chemistry Expertise
Our team has been working with complex halogenated and heterocyclic chemistries since 2011, beginning with Sodium Picramate and Picramic Acid before expanding into a portfolio of over 25 pharmaceutical and specialty intermediates. The process knowledge required to manufacture 7-Chloroquinaldine with the consistency pharma synthesis demands — controlling reaction selectivity, managing by-product formation, and maintaining yield across batches — has been built through years of hands-on production, not acquired recently.
ISO 9001:2015 Certified Quality System
Our manufacturing facility operates under an ISO 9001:2015 certified quality management system. Every batch of 7-Chloroquinaldine undergoes in-house quality verification, and a Certificate of Analysis is issued per batch. For buyers in regulated industries, this is not a bonus — it is a baseline requirement we already meet.
Flexible Supply for Every Project Stage
Whether you are at the process development stage and need a small custom quantity to evaluate, or you are a commercial API manufacturer requiring consistent bulk supply, we structure our output around your requirement. We do not impose rigid packaging tiers. Contact us with your volume and timeline and we will confirm availability, pricing, and lead time directly.
Trusted by CRAMS and CDMO Companies Across India
We grew from 2 clients in 2021 to over 20 in 2025 — the majority of them pharmaceutical CRAMS and CDMO organisations that demand multi-batch consistency and long-term supply reliability. Our client retention reflects what no certificate can fully convey: that when we commit to supply, we deliver.
Buy 7-Chloroquinaldine at the Best Price — Direct from Manufacturer
Because you are purchasing directly from the manufacturer with no trading intermediary, our pricing reflects actual production cost rather than a marked-up resale price. For bulk buyers, this difference is material. We are also able to discuss long-term supply agreements for organisations requiring volume commitments and price stability over multiple production cycles.
Global Supply with Full Export Documentation
We supply to customers across India and internationally. Our team can assist with COA, MSDS, and all relevant export documentation — including requirements specific to your destination country — ensuring a smooth import process on your end.
Related Products You May Also Need
Customers sourcing 2-Hydroxy-1-Naphthaldehyde often also require the following intermediates from our portfolio:
- Isatin (CAS 91-56-5) — Pharma intermediate & Solvent Yellow 114 precursor
- 7-Chloroquinaldine (CAS 4965-33-7) — Montelukast Sodium MK-1 intermediate
- 3-Hydroxyquinaldine-4-carboxylic acid (CAS 117-57-7) — Solvent Yellow 114 & Disperse Yellow 54 intermediate
- 4-Diethylamino salicylaldehyde (CAS 17754-90-4) — Specialty dye intermediate for Solvent Yellow 172, Coumarin 7
View our complete product range on the Pharma Intermediate and Specialty Intermediate pages.
Frequently Asked Questions
What is 7-Chloroquinaldine used for?
7-Chloroquinaldine (CAS 4965-33-7) is primarily used as a pharmaceutical intermediate in the synthesis of Montelukast Sodium, a globally prescribed asthma and allergic rhinitis drug. It is also used as a precursor in the manufacture of Quinophthalone dyes for engineering plastics and LEDs.
Who is the manufacturer of 7-Chloroquinaldine in India?
Advance Pharma Chem is India’s first and most established commercial manufacturer of 7-Chloroquinaldine. The compound is produced in-house at our ISO 9001:2015 certified facility and supplied to pharmaceutical and specialty chemicals companies across India and internationally.
What is the CAS number for 7-Chloroquinaldine?
The CAS number is 4965-33-7. It is also referred to as 7-Chloro-2-methylquinoline.
Can I buy 7-Chloroquinaldine in bulk from Advance Pharma Chem?
Yes. We supply custom quantities — from small R&D batches to large commercial bulk volumes. Contact us with your requirement and we will confirm pricing, availability, and lead time.
Is Advance Pharma Chem a manufacturer or a trader?
We are the manufacturer. We developed the commercial-scale production process for 7-Chloroquinaldine in India entirely in-house. We do not source and resell — we produce and supply directly.
What is the best price for 7-Chloroquinaldine?
As a direct manufacturer with no intermediary, our pricing reflects actual production costs. For the most accurate and competitive quote, contact us directly with your quantity requirement. Bulk orders and long-term supply agreements are eligible for preferential pricing.
Is a Certificate of Analysis (COA) available?
Yes. A COA is issued for every batch manufactured. Please mention your COA requirement when placing your enquiry and we will ensure it is included with your shipment documentation.
What are the storage conditions for 7-Chloroquinaldine?
Store in a cool, dry, well-ventilated place away from direct light and heat. Keep in a tightly sealed container. Refer to the full MSDS for comprehensive storage and handling guidance.
Do you supply 7-Chloroquinaldine internationally?
Yes. We supply to customers in India and internationally. We assist with all required export documentation including COA, MSDS, and destination-specific customs paperwork.
What is the molecular formula of 7-Chloroquinaldine?
The molecular formula is C₁₀H₈ClN with a molecular weight of 177.63 g/mol.
What is the lead time for 7-Chloroquinaldine orders?
The compound is maintained in stock. Lead time depends on order quantity and current production schedule. We recommend contacting us early for commercial volumes. Development quantities are typically fulfilled faster.
Is 7-Chloroquinaldine the same as 7-Chloro-2-methylquinoline?
Yes. 7-Chloro-2-methylquinoline is the IUPAC-aligned synonym for 7-Chloroquinaldine. Both names refer to the same compound with CAS number 4965-33-7.