2-Hydroxy-1-Naphthaldehyde
2-Hydroxy-1-Naphthaldehyde Manufacturer in India
What is 2-Hydroxy-1-Naphthaldehyde?
2-Hydroxy-1-Naphthaldehyde is an aromatic aldehyde derivative of naphthalene, carrying both a hydroxyl group at the 2-position and an aldehyde group at the 1-position of the naphthalene ring. It has the molecular formula C₁₁H₈O₂ and a molecular weight of 172.18 g/mol, registered under CAS number 708-06-5. It is also known by the synonyms 2-Naphthol-1-carboxaldehyde, β-Naphthol aldehyde, and 1-Formyl-2-naphthol.
The combination of the reactive aldehyde group and the adjacent hydroxyl group on the naphthalene framework is precisely what makes this compound a valuable and difficult-to-substitute building block in both pharmaceutical and specialty dye synthesis. The bifunctional nature of the molecule enables selective condensation and chelation reactions that underpin its downstream applications.
At Advance Pharma Chem, 2-Hydroxy-1-Naphthaldehyde is manufactured through a controlled in-house synthesis process with rigorous quality verification at every production stage — from raw material intake to finished goods dispatch — ensuring the purity and batch-to-batch consistency that pharmaceutical API manufacturers and specialty chemical producers demand.
2-Hydroxy-1-Naphthaldehyde is an aromatic aldehyde derivative of naphthalene, carrying both a hydroxyl group at the 2-position and an aldehyde group at the 1-position of the naphthalene ring. It has the molecular formula C₁₁H₈O₂ and a molecular weight of 172.18 g/mol, registered under CAS number 708-06-5. It is also known by the synonyms 2-Naphthol-1-carboxaldehyde, β-Naphthol aldehyde, and 1-Formyl-2-naphthol.
The combination of the reactive aldehyde group and the adjacent hydroxyl group on the naphthalene framework is precisely what makes this compound a valuable and difficult-to-substitute building block in both pharmaceutical and specialty dye synthesis. The bifunctional nature of the molecule enables selective condensation and chelation reactions that underpin its downstream applications.
At Advance Pharma Chem, 2-Hydroxy-1-Naphthaldehyde is manufactured through a controlled in-house synthesis process with rigorous quality verification at every production stage — from raw material intake to finished goods dispatch — ensuring the purity and batch-to-batch consistency that pharmaceutical API manufacturers and specialty chemical producers demand.
Product Specifications
| Product Name | 2-Hydroxy-1-Naphthaldehyde |
|---|---|
| CAS Number | 708-06-5 |
| Molecular Formula | C₁₁H₈O₂ |
| Molecular Weight | 172.18 g/mol |
| IUPAC Name | 2-Hydroxynaphthalene-1-carbaldehyde |
| Synonyms | 2-Naphthol-1-carboxaldehyde; β-Naphthol aldehyde; 1-Formyl-2-naphthol |
| Appearance | Pale yellow to yellow crystalline solid |
| Purity | 99%+ (available on request) |
| Packaging | 30 kg drums/ custom packaging available |
| Storage Conditions | Store in a cool, dry, well-ventilated area away from direct sunlight |
| HS Code | 2912.29 (Aromatic aldehydes) |
Applications of 2-Hydroxy-1-Naphthaldehyde (CAS 708-06-5)
2-Hydroxy-1-Naphthaldehyde is a high-value intermediate used across two distinct industrial segments — regulated pharmaceutical synthesis and high-performance specialty dye and pigment manufacturing. Its bifunctional reactivity makes it effectively non-substitutable in several key downstream processes.
Pharmaceutical Applications
Nafcillin Antibiotic — Anti-Staphylococcal Treatment
The primary pharmaceutical application of 2-Hydroxy-1-Naphthaldehyde is as a direct precursor in the synthesis of Nafcillin, a semisynthetic, penicillinase-resistant antibiotic used in the treatment of serious Staphylococcal infections including those caused by methicillin-susceptible Staphylococcus aureus (MSSA). Nafcillin is administered intravenously in hospital settings and remains an important drug in the management of bacteraemia and endocarditis. For API manufacturers producing Nafcillin or its intermediates, a reliable, high-purity source of 2-Hydroxy-1-Naphthaldehyde is a direct supply chain requirement.
Sirtinol — Cancer Biology & Ageing Research
2-Hydroxy-1-Naphthaldehyde is also used as a key building block in the synthesis of Sirtinol, a cell-permeable sirtuin inhibitor (Sir2 inhibitor) used extensively in biological research. Sirtinol is an important research tool compound in programmes studying cancer cell proliferation, cellular ageing, and epigenetic regulation. The compound is actively used in academic and pharmaceutical R&D settings, creating consistent demand for high-purity 2-Hydroxy-1-Naphthaldehyde from research-focused buyers.
Custom API & Research Synthesis
Beyond these established applications, the bifunctional structure of 2-Hydroxy-1-Naphthaldehyde makes it a versatile building block in custom synthesis programmes. It is used in the development of novel heterocyclic compounds, Schiff base ligands, and coordination chemistry research — expanding its buyer base to custom synthesis organisations, CRAMS companies, and university research groups.
Specialty Dye & Pigment Applications
Pigment Yellow 101 (Aldazine Yellow) — Fluorescent Pigment for Plastics & Coatings
In the specialty chemicals segment, 2-Hydroxy-1-Naphthaldehyde is a key intermediate in the synthesis of Pigment Yellow 101 (also known as Aldazine Yellow), a high-performance fluorescent organic pigment widely used in plastics colouration and paint formulations. Pigment Yellow 101 is valued for its exceptional lightfastness and brightness, making it suitable for outdoor applications and demanding coating systems.
Additional High-Performance Pigments & Dyes
- Pigment Yellow 129 — High-performance organic pigment for industrial coatings and automotive finishes.
- Pigment Orange 70 — Pigment intermediate used in automotive OEM coatings.
- Solvent Violet 49 — Specialty solvent dye for plastic mass colouration.
- Solvent Red 212 — Dye used in fuel marking and plastic identification applications.
This dual relevance — serving both pharmaceutical and specialty dye buyers — makes 2-Hydroxy-1-Naphthaldehyde one of the more strategically important intermediates in our product portfolio.
Why Source 2-Hydroxy-1-Naphthaldehyde from Advance Pharma Chem?
In-House Manufacturing — Not a Trader or Reseller
2-Hydroxy-1-Naphthaldehyde is manufactured entirely in-house at our facility in Mumbai. We do not source this compound from third parties and resell it. When you place an order with us, you are purchasing from the producer — which directly translates to tighter quality control, faster response to custom requirements, and pricing that reflects actual manufacturing cost rather than a marked-up resale margin.
14+ Years of Aromatic & Heterocyclic Process Chemistry Expertise
Our team has been working with complex aromatic and heterocyclic chemistries since 2011, building deep process knowledge across over 25 pharmaceutical and specialty intermediates. The controlled synthesis required to produce 2-Hydroxy-1-Naphthaldehyde at consistent purity — managing selectivity of the formylation reaction and controlling by-product formation — requires process expertise that we have built through years of hands-on manufacturing, not recently acquired capability.
ISO 9001:2015 Certified Quality System
Our manufacturing facility operates under an ISO 9001:2015 certified quality management system. Every batch of 2-Hydroxy-1-Naphthaldehyde undergoes in-house quality verification before dispatch, and a Certificate of Analysis is issued per batch. For pharmaceutical and specialty chemical buyers operating in regulated supply chains, this is a baseline requirement we already meet.
Purity Grade Suitable for Pharma Intermediate Use
We supply 2-Hydroxy-1-Naphthaldehyde at ≥ 98% purity as our standard grade — the purity level required for use as a pharmaceutical intermediate. Custom purity specifications and documentation requirements can be accommodated on request. We do not supply commodity-grade material marketed as pharma-suitable.
Flexible Supply from R&D Quantities to Commercial Bulk
Whether you are evaluating the compound at the process development stage and need a small quantity with full documentation, or you are a commercial manufacturer requiring consistent bulk supply across multiple production cycles, we structure our output around your requirement. Standard packaging is in 25 kg drums; smaller quantities are available on request with no rigid minimum order constraint.
Trusted by Pharma & Specialty Chemical Manufacturers Across India
We have grown from 2 clients in 2021 to over 20 in 2025 — spanning pharmaceutical API manufacturers, CRAMS organisations, specialty dye producers, and research institutions. Our client retention reflects consistent supply performance: when we commit to a batch schedule, we deliver on it.
Global Supply with Full Export Documentation
We supply to customers across India and internationally. Our team assists with COA, MSDS, and all relevant export documentation — including destination-specific requirements — ensuring a smooth import process on your end.
Related Products You May Also Need
Customers sourcing 2-Hydroxy-1-Naphthaldehyde often also require the following intermediates from our portfolio:
- Isatin (CAS 91-56-5) — Pharma intermediate & Solvent Yellow 114 precursor
- 7-Chloroquinaldine (CAS 4965-33-7) — Montelukast Sodium MK-1 intermediate
- 3-Hydroxyquinaldine-4-carboxylic acid (CAS 117-57-7) — Solvent Yellow 114 & Disperse Yellow 54 intermediate
- 4-Diethylamino salicylaldehyde (CAS 17754-90-4) — Specialty dye intermediate for Solvent Yellow 172, Coumarin 7
View our complete product range on the Pharma Intermediate and Specialty Intermediate pages.
Frequently Asked Questions
What is 2-Hydroxy-1-Naphthaldehyde used for?
2-Hydroxy-1-Naphthaldehyde (CAS 708-06-5) is primarily used as a pharmaceutical intermediate in the synthesis of Nafcillin antibiotic and Sirtinol (a sirtuin inhibitor used in cancer research). It is also a key intermediate in the production of high-performance pigments and dyes including Pigment Yellow 101, Pigment Yellow 129, Pigment Orange 70, Solvent Violet 49, and Solvent Red 212.
Who manufactures 2-Hydroxy-1-Naphthaldehyde in India?
Advance Pharma Chem manufactures 2-Hydroxy-1-Naphthaldehyde in-house at our ISO 9001:2015 certified facility in Mumbai, India. We supply pharmaceutical companies, specialty dye manufacturers, and research institutions across India and internationally.
What is the CAS number for 2-Hydroxy-1-Naphthaldehyde?
The CAS number is 708-06-5. It is also referred to as 2-Naphthol-1-carboxaldehyde, 1-Formyl-2-naphthol, or β-Naphthol aldehyde — all names refer to the same compound.
What purity grade is available?
We supply 2-Hydroxy-1-Naphthaldehyde at ≥ 98% purity as our standard grade. Custom purity specifications are available upon request for specific pharmaceutical or research requirements.
Is Advance Pharma Chem a manufacturer or a trader?
We are the manufacturer. 2-Hydroxy-1-Naphthaldehyde is produced entirely in-house at our Mumbai facility. We do not source and resell — we manufacture and supply directly, which means better quality control and more competitive pricing for our customers.
Can I buy 2-Hydroxy-1-Naphthaldehyde in bulk?
Yes. We supply from small R&D quantities up to large commercial bulk volumes. Standard packaging is in 25 kg drums. Contact us with your volume requirement and we will confirm pricing, availability, and lead time.
What is the best price for 2-Hydroxy-1-Naphthaldehyde?
As a direct manufacturer with no trading intermediary, our pricing reflects actual production costs. For the most accurate and competitive quote, contact us with your quantity requirement. Bulk orders and long-term supply agreements are eligible for preferential pricing.
Is a Certificate of Analysis (COA) available?
Yes. A COA is issued for every batch manufactured. Please mention your COA requirement when placing your enquiry and we will ensure it is included with your shipment documentation.
What are the storage conditions for 2-Hydroxy-1-Naphthaldehyde?
Store in a cool, dry, well-ventilated place away from direct light and heat. Keep in a tightly sealed container. Refer to the full MSDS for comprehensive handling and storage guidance.
Do you supply 2-Hydroxy-1-Naphthaldehyde internationally?
Yes. We supply to customers in India and internationally. We assist with all required export documentation including COA, MSDS, and destination-specific customs paperwork.
What is the lead time for orders?
The compound is maintained in stock. Lead time depends on order quantity and current production schedule. Development quantities are typically fulfilled faster. We recommend contacting us early for commercial-volume orders.
What is the molecular formula of 2-Hydroxy-1-Naphthaldehyde?
The molecular formula is C₁₁H₈O₂ with a molecular weight of 172.18 g/mol. The IUPAC name is 2-Hydroxynaphthalene-1-carbaldehyde.
Is 2-Hydroxy-1-Naphthaldehyde the same as 2-Naphthol-1-carboxaldehyde?
Yes. 2-Naphthol-1-carboxaldehyde is a common synonym for 2-Hydroxy-1-Naphthaldehyde. Both names refer to the same compound with CAS number 708-06-5.